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Publication details

The effect of timing of teriparatide treatment on the circadian rhythm of bone turnover in postmenopausal osteoporosis

Journal Article

Luchavová M., Zikán V., Michalská D., Raška I., Kuběna Aleš Antonín, Štěpán J. J.


serial: European Journal of Endocrinology vol.164, 4 (2011), p. 643-648

research: CEZ:AV0Z10750506

project(s): NS10564, GA MZd

keywords: intact parathyroid-hormone, serum cortisol, diurnal rhythm, growth-hormone, in-vivo, resorption, osteoprotegerin, calcium, abnormalities, osteocalcin

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abstract (eng):

We hypothesized that with the administration of teriparatide (TPTD) treatment at different times, we would be able to modify the physiological circadian rhythm of bone turnover. The concentration of serum C-terminal telopeptide of collagen type I (beta CTX), serum N-terminal propeptide of procollagen type I (P1NP), serum ionized calcium (iCa), and plasma PTH were measured every 3 h over a 24 h period in 14 postmenopausal osteoporotic women (aged 72.4 +/- 9.3 years) treated with 20 mu g TPTD for long term, given at different times of the day. General linear model-repeated measurements (GLM RM) were performed to analyze the circadian rhythms as well as intergroup comparisons.

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Last modification: 21.12.2012
Institute of Information Theory and Automation